Tuesday, August 27, 2013

Understanding Drivers Within Cancer Research

By Rob Sutter


An article was posted on Futurity.org and it went into detail about drivers and how they play into cancer research. It was the kind of subject that I was unfamiliar with, so I decided to read on and I found myself learning more and more about these drivers. Basically, each one is linked to a related condition and when the driver itself is brought down, along with it goes the condition. However, talking about glioblastoma is a more complicated matter and there are a couple of reasons for this.

Glioblastoma is recognized in cancer research for a number of reasons but its prevalence is perhaps one of the most important aspects. It is not only the most common type of growth seen in the brain but it is also the most aggressive. Add in the fact that it is a complex growth and it is clear as to why organizations like Voices against Brain Cancer have placed so much focus on it. Where does the idea of "drivers" come into play, you may wonder?

The article talked about glioblastoma and how 15 percent of those particular cases can be helped thanks to the slew of current drugs put into place. These drugs are FDA-approved as well, so it is apparent that they can help the body as opposed to harm it. The problem is that these growths are some of the most intricate and this means that research methods beforehand have had limited success. There's a focus on targeting all "drivers," which is difficult to do in this field.

There was a study done by the Columbia University Medical Center and it was able to put a couple of ideas into practice. The article said that a combination of high throughput DNA sequencing as well as statistical analysis was able to prove helpful. The reason for this is because a short list of driver candidates were created, therefore making research methods that much more essential. The study in question was massive, seeing as how almost 140 tumor types were looked into with the utmost focus.

Cancer research is immensely important and I feel as though the idea of scope should be kept in mind. You never want to limit said scope because this is what is needed in order to bring the best results to the surface. The more that you're able to bring to the table, the greater that your findings are and the more you'll be able to learn about cancer in general. It is clear that the "drivers" are looked into with great focus and I think that it's easy to see why.




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